Cardarine GW501516: The Complete No Bullshit Guide

Cardarine GW501516: The Complete No Bullshit Guide

What Is Cardarine? Can It Really Increase Endurance and Burn Fat?

Cardarine (GW – 501516), also known as Enfurobol, was developed initially as an alternative treatment for several conditions, including metabolic syndrome and heart disease.

Athletes and bodybuilders began using Cardarine for its unique ability to reduce recovery time, increase endurance, and burn fat while maintaining muscle mass.

Although often called a SARM(Selective Androgen Receptor Modulator), and frequently used in combination, Cardarine itself is not a SARM, it is a PPAR-delta pathway activator.

Cardarine activates the PPAR–delta protein; a sensor for fatty acids which reside in muscle tissue. Your ability to burn fat increases once this protein is activated. The result is that you burn fat without affecting the muscle.

In this article, you will learn about the origins of Cardarine, its benefits, and side effects along with dosage and cycle information. We will also discuss how to stack Cardarine with SARMs. You will have enough information required to make an informed decision.


Two pharmaceutical companies, Ligand Pharmaceuticals, and GlaxoSmithKline, began developing it in the early 1990s.

Cardarine’s initial purpose was to slow the formation of tumors, as well as a means for stabilizing lipid levels and promote healthy blood cholesterol. It was intended to lower the risk for disease by the effect it had on tissues.

Over time, as studies were performed, Cardarine became better known for its enhancement of fat loss, especially belly fat, and physical transformation.

Studies of the drug began in the year 2000, and by 2007 GSK had completed two phase 2 clinical studies and others regarding obesity, diabetes, and cardiovascular disease, among others. But, further development was abandoned that same year, as animal studies showed the rapid growth of cancer in several organs of mice and rats.

Later that year, research from other laboratories discovered that Cardarine had a significant impact on physical performance in mice.


There are many benefits to Cardarine.

  • Helps Burn Fat

Cardarine works within the cell to stop the synthesis of fatty acids. Being a PPAR–delta it can activate a significant number of fat burning genes. Cardarine can help the body convert stored fat to energy, and enhance metabolism.

  • Increases Stamina and Muscle Growth

Scientists have found that activating the PPAR–delta pathway improves endurance, stimulates muscle growth, burns fat, and increases energy. Cardarine is among only a few compounds that can stimulate this pathway.

  • Protects Heart and Blood Vessels

Cardarine increases nitrous oxide levels in the blood as well as prohibiting oxidative damage to the blood vessels. It has been shown to promote new blood vessel growth in human heart cells. It also lowers inflammation and tissue damage.

  • Reduces the Chance of Kidney Inflammation

Cardarine can substantially decrease the incidence of kidney inflammation and causes the genes associated with kidney disease to slow down.

  • It Is Antioxidant

Once again, using the PPAR–delta pathway, Cardarine not only suppresses inflammation in organs like the liver, but it can even work its magic at the DNA level. At this level, just as in the kidney, the inflammatory genes are slowed down.

It has been found to improve the survival of skin cells, stop inflammatory molecules from being produced, and increases beneficial antioxidant enzymes.

  • High Bioavailability

Cardarine is easily assimilated into your system, which means that you are able to get the results you want with smaller doses.

As significant as these benefits are, Cardarine also has a positive impact on glucose levels as well as improving recovery times. It is nonhormonal, enhances metabolism, and is not a stimulant.

Side Effects

While there have not been any large-scale human studies, it is essential to know that in animal studies, Cardarine was shown to affect fetal development if used during pregnancy.

Because of limited human studies, the potential side effects are not established. Although some animal studies showed it to be a possible carcinogen, other studies have shown that it aids in the prevention of tumors. Especially tumors of the skin and breast. Similar results were seen in the case of colon and prostate tumors.

Although it has many amazing attributes, and it has been in use for some time, in athletics and bodybuilding specifically, Cardarine is currently available for research only. If you do choose to experiment with this drug, you should keep this in mind.

Recommended Dosage and Cycle

When considering how you want to use Cardarine, you need to keep in mind that it is currently not recognized by the FDA. Therefore, there are no established parameters for dosage.

That being said, in the few human trials that have taken place, the typical dosage was from 2.5 mg to 10 mg per day for 12 weeks. Whatever amount you determine is appropriate for you, most current users recommend a 6 to 12-week maximum period of usage with a 4 to 6-week break between cycles.

Everybody’s health and physiology is different. It is best to start at a lower dose and build beyond that as needed. Typically, 10 mg is where most people tend to start. The dosage is the same for both men and women, unlike many other drugs and compounds. But again, you must determine the appropriate dosage for yourself. It is recommended that the first cycle be no longer than six weeks.

Generally, whether you are burning fat or building muscle, 10 mg to 20 mg is the range. In the case of extreme obesity, you may end up at 30 mg. Other than that factor, body weight does not influence the dosage.

For bodybuilding and endurance training, it is often recommended that Cardarine be taken about three hours before your workout. In some cases, it may be beneficial to split the dosage. Cardarine has a half-life of about 24 hours.

Due to its potential for abuse, both the International Olympic Committee and the World Anti-Doping Agency have band Cardarine and other similar substances.

Stacking Cardarine with Other SARMS

Because Cardarine burns fat and builds muscle, it is an ideal addition to a cutting stack. It works well with most SARMS and steroids since it’s anti-inflammatory and other innate attributes counteract some of the negative impact experienced with other substances.

One of the most simple and common stacking combinations is Cardarine and Ostarine. Andarine is also commonly added to this combination.

You may find it useful to add 20 mg of Cardarine to your preferred SARMS stack during certain cycles.

Many athletes say that they find Cardarine particularly beneficial by using a smaller dose such as 10 mg while recuperating.


Whether you are merely looking to lose belly fat, trying to bulk up, or preparing for competition, Cardarine has something to offer.

Initially created to tackle some of our most challenging health issues today, it has an impressive list of qualities. It may help with type II diabetes as it reduces insulin resistance, lowering glucose levels by allowing the cells to accept more fuel. It can protect your heart and vascular system from inflammation and helps blood vessels become more elastic.

Just keep in mind that this is not a scheduled drug. There have been very few human trials, and so far and those have been small. Be prudent with your research and make sure that you are purchasing a quality product from a reputable source.

Since Cardarine is not approved or scheduled, products available in a retail setting are suspect and very possibly fake. Make sure that you are purchasing research quality product, and pay close attention to how it works and affects your body.

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