Sulbutiamine Review: An Energy Booster For Mind and Body

Introduction to Sulbutiamine

Sulbutiamine is a synthetic chemical that is touted as a great help in dealing with the fatigue and improving your brain function, among many other benefits. For stress affected people slowed down by fatigue and tiredness, not to mention mental fogginess, this chemical should come as the greatest news to hear.
But how well does sulbutiamine perform this task and how different is it from other nootropics? Keep reading to find out what this special compound is, its history, uses, and whether it can benefit you.


For most people today, beriberi isn’t an illness that rings a bell. However, many years ago, this condition was a terror to the Japanese authorities who were grappling to control it in their country.

World War II had stripped Japan of sufficient food sources of thiamine, and the population came to rely heavily on rice as their main diet. As a result, many succumbed to a disorder of the central nervous system called beriberi.

Beriberi is a serious illness that can lead to heart failure, paralysis, and even death.
Japanese researchers then went to work in their labs to get a solution.
The result was sulbutiamine, a synthetic molecule with two vitamins or thiamine joined together. It proved to be dramatically more effective than ordinary thiamine in overcoming thiamine deficiency.
Sulbutiamine is also known by several brand names such as Arcalion, Youvitan, Enerion, and Bisibuthiamine.

It is in France where sulbutiamine first went commercial in 1973, being marketed under the brand name Arcalion. The company behind it was Servier.
Sulbutiamine is offered both as a drug and as a supplement. Its use as a supplement for bodybuilders has increased due to its ability to provide energy boosts and an increase in mental focus and concentration.


What are the benefits of sulbutiamine? The benefits of sulbutiamine have been discovered to be the following: Improved cognition performance and memory

  • Fatigue that is related to injury

those with chronic fatigue caused by brain damage or infection has benefited by having their energy boosted through this vitamin nutrient. However, studies show that this benefit only occurs when it is used for a short time, such as two weeks. It was found that people who used it for about a month did not see any improvement in their fatigue situation

  • Fatigue that is related to Multiple Sclerosis

this condition was relieved in patients who used the vitamin nutrient for 6 month

  • Fatigue with unknown causes

sulbutiamine may also provide anti-fatigue benefits for general fatigue beyond those resulting from injury and Multiple Sclerosis

  • Erectile dysfunction

clinical studies are showing that men with ED experienced some improvement when they used the nutrient for one month. Keep in mind that this was only for ED patients whose condition was brought about by psychological issues. ED brought about by physical causes, however, may not benefit.

  • Memory enhancement and mental alertness levels

through its action of boosting some neurotransmitters like choline, this vitamin can increase long-term memory. This effect is especially enhanced when it is taken together with donepezil (an Alzheimer’s disease drug). In one study, Alzheimer’s patients experienced better memory and attention after using sulbutiamine for six months

  • Neuroprotection

users also get to benefit by having their brains protected from harm. One study showed that when brain cells starved of nutrients were treated with sulbutiamine, they lived longer than those that were not treated with it.
Curbs anxiety and enhances your mood – studies show that those who suffer severe depression and anxiety, experienced relief from taking this molecule. The compound achieves this by activating the production of dopamine and glutamate, two neurotransmitters which can increase feelings of pleasure and calm

  • Can also improve your digestion

Treatment of thiamine deficiency – it has a different structure from the standard thiamine. This makes it have greater bioavailability than the standard thiamine in the brain. It makes an excellent alternative to the standard thiamine to ensure your body does not lack in it

Has antioxidant benefits – it has the role of protecting your cells against the damage caused by free radicals. Antioxidation promotes longevity of cells and maintains their youthfulness.

Side effects

Sulbutiamine shows very few side effects in users. Some side effects such as depression and irritability y can result from an overdose. Other side effects that are likely to be seen are:
• Headache
• euphoria
• Sleep problems
• Stomach upset
• Skin rash or eczema-like symptoms
• Elderly people may experience mild agitation
• Depression
• Anxiety
• Irritability

Some side effects are also seen when it is used together with other medications. E.g., taken with antibiotics users may experience tremor, diarrhea, drowsiness, headache, and insomnia. For this reason, always check with your doctor before using sulbutiamine if you are under medication.

Nature and composition

Sulbutiamine is a combination of two thiamine or Vitamin B1 molecules. The two are held together by a sulfur group so that it can be delivered as one molecule into the body.


We don’t yet have an ideal dosage of sulbutiamine, and this is an area that is still being studied.

Some studies show that sulbutiamine is best taken with food at a dosage of 200 mg to 300mg per day. This can be taken two or three times a day.

You can also stack sulbutiamine with other supplements for better results.
For example, patients being treated for depression had recovered even faster when they stacked the vitamin together with clomipramine, which is an antidepressant.

Other stacking strategies include the following:

  • Stacking with Aniracement and Choline:
  • Stacking with a racetam nootropic like Aniracment is a popular choice because of its supporting role of enhancing mood and cognition. Here is the recommended dosage of sulbutiamine
  • 200 mg of
  • 750 mg of Aniracement
  • 300 mg of Alpha GPC
  • This stack is to be taken one to two times a day.
  • Stacking with Huperzine A and Choline:
  • Extracted from an Irish moss plant, Huperzine A works by blocking or slowing down the breakdown of acetylcholine, the molecule that gives you enhanced mental focus and alertness. The recommended dosage is
  • 200 mg of sulbutiamine
  • 200 mcg of huperzine A
  • 300 mg of Alpha GHC
  • This stack can also be taken 1 to 2 times a day.

Price and availability
You can grab your sulbutiamine supplement either in capsule or powder form.
The powder form can be obtained in bulk amounts and is more pocket-friendly. However, the capsule form is a lot easier to use because it is convenient when deciding the dosages to take.
Although you can find the supplement from a brick and mortar store, online sellers can provide you with much lower prices. Just make sure you have bought from a reputable seller and that the seller can provide a certificate of analysis for it.

How sulbutiamine acts

Sulbutiamine is a two-thiamine molecule that is more efficiently absorbed by the brain. This is because being fat-soluble, it can cross the brain-blood barrier, unlike its standard cousin, the single thiamine vitamin which is water-soluble.
Once in the brain, it delivers its benefits through a complex variety of actions. It triggers the production of thiamine triphosphate. This substance then controls the release of some very useful neurotransmitters such as dopamine, glutamate, and acetylcholine. They are the agents who are involved in creating a happy mood or making you less depressed.

Compared to thiamine, sulbutiamine excels in the following ways:
• It is has a higher absorption rate in the intestines, which means more of it will be available for the body compared with thiamine.
• When very high amounts of thiamine are present in the gut, its absorption rate is lessened even further. This is not the case with sulbutiamine
• Sulbutiamine increases the number of dopamine receptors in neurons. Dopamine generates positive feelings of pleasure and can enhance motivation, focus, and productivity. This makes sulbutiamine better than thiamine in reaching these goals.

Sulbutiamine vs. Sibutramine

These two can sound a lot similar, but they are not the same. Sibutramine is used as an appetite suppressor and should not be confused with the former.

• Not addictive
• Fat-soluble so it can enter the brain barrier more efficiently than thiamine
• Rapid results can be obtained in many cases. Motivation, focus, and better mood featured among most of these results

It is synthetic and not a natural based substance
• Cannot be used for long-term
• Can be addictive for some people
• Some people experience no difference from using it
• Some of the studies did not provide for control groups which could lead to biased results
• Not enough humans studies have been done for some of the claimed benefits


Sulbutiamine is a very potent substance that has helped many people overcome chronic physical and mental fatigue as well as improve mental focus and concentration.
These problems can be relieved if you suffer from a thiamine deficiency. However, sulbutiamine can also benefit you even if you are healthy and have no thiamine deficiency. If you just want to boost your mental focus and enhance your memory, this potent vitamin can be ideal for you.

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