Ostarine (MK2866): The NO Bullshit Guide to this SARM

A complete guide to Ostarine

Selective Androgen Receptor Modulators (SARMs) are red-hot in the fitness community today – and for good reason.

Providing many of the same benefits that traditional anabolic steroids and other performance-enhancing drugs bring to the table without the same side effects – or any real serious side effects, for that matter – amateur bodybuilders, professional athletes, and weekend warriors are finding SARMs like Ostarine give them an extra edge and advantage to transform their bodies faster.

mk2866 picture

Ostarine, in particular, is a relatively new SARM but already it is one of the most popular options on the market. Designed to provide rapid muscle mass generation, improvements to strength and endurance, and a host of other benefits it’s hard to imagine anyone serious about their fitness not looking closely at this near side effect free performance enhancement solution.


Like many other SARMs, Ostarine was originally intended to be a medical solution that could effectively treat serious medical conditions that involved muscle wasting, muscle atrophy, and muscular degeneration.

The laboratory behind Ostarine, GTX, developed this SARM initially as a solution for those suffering from osteoporosis. This compound was developed between 1997 and 2007, entering into its Phase 2 trials in 2007.

These initial trials failed to treat muscular wasting in those that had been diagnosed with lung cancer, but with a new investment of $35 million to further develop this chemical compound and to better understand what it was capable of it’s now regarded as an effective solution for those suffering from prostate cancer.

Another round of Phase 2 trials began in 2016 to see if Ostarine could be an effective solution for urinary incontinence in women, but these trials have yet to conclude and we are still unsure of its short or long-term impact in this area.

As far as its performance-enhancing properties are concerned, however, the bodybuilding, fitness, and athletics community has embraced pretty much everything Ostarine has to offer and has done so right out of the gate.

Like all other SARMs Ostarine has been banned as a performance-enhancing substance at the collegiate and professional levels in the United States, and the WADA has also drawn a hard line in the sand banning it from use in international competitions as well.

That hasn’t stopped folks around the world from taking advantage of the performance-enhancing benefits Ostarine makes possible, though, particularly those that do not have to worry about independent drug testing and potential banishments from amateur and professional contests.

Ostarine before and after 8 weeks cycle


The way Ostarine works is relatively simple and straightforward, and that’s what makes the amazing benefits it offers so special.

Effectively binding with a number of very specific androgen receptors that already exist in your muscles as well as your bones, Ostarine helps these androgen receptors to “fire off” more frequently and to take full advantage of all steroidal hormones – like testosterone, DHT, and estrogen – to mimic the exact same kind of benefits that could be produced by external sources of testosterone (like you get from anabolic steroids, for example).

Basically, Ostarine works the same way that a milder steroid wouldhelping you build muscle faster, recover faster, etc. – without any of the negative side effects that those kinds of chemical compounds inevitably bring to the table.

In clinical trials, a 12-week cycle of Ostarine was able to help more than 120 healthy elderly individuals gain upwards of 8 pounds of lean muscle mass that they wouldn’t have been able to gain otherwise.

Bodybuilders that take advantage of this same chemical compound should expect to add significantly more than that in the same 12 week span of time – not only because their bodies are usually quite younger, but also because most bodybuilders go with a dosage of 25 mg per day (something will dive into in-depth in just a moment).

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On top of that, the muscle mass gains generated through Ostarine usage have proven to be significantly more permanent than those you can generate with traditional anabolic steroids and other performance-enhancing drugs.

These chemical compounds “lock-in” and cement 97% of the lean muscle mass that you are able to generate, with an average 3% lean muscle mass loss that can occur between two weeks and four weeks post cycle.

With proper Post Cycle Therapy (PCT) you can almost all but eliminate any of that lean muscle mass loss as well – something that cannot be said about the mass you inevitably lose when you come off of traditional anabolic steroids.

It’s not uncommon to see other benefits when you’re using Ostarine, either, benefits like:

  • Improved overall bone health and bone density
  • Improved lipid profiles
  • Improved insulin resistance

… And that’s just the tip of the iceberg!

Side Effects

As we have made mention of a number of times throughout this quick Ostarine guide, you aren’t going to have to worry about any of the short-term or long-term side effects that traditional anabolic steroids and other performance-enhancing drugs inevitably bring about when you use this SARM.

Anecdotal evidence reports some mild side effects that you may or may not have to contend with, however, side effects that can include:

  • Heat waves and hot flashes
  • Elevated sweating levels
  • Lethargy and difficulty sleeping
  • Mild headaches

… Other than that, however, there really isn’t a lot to worry about should you choose to take advantage of this powerful SARM.

More in-depth research is necessary to fully understand the long-term potential health impacts of SARMs in general as these compounds are still quite new, but so far everything looks quite promising.

Dosage and Cycle

Individual dosages and cycles of this SARM are going to vary for a variety of different reasons, but on average most people recommend a 25 mg per day dosage for between 8 weeks and 12 weeks for a single cycle of this compound.

People that haven’t used this compound in the past probably aren’t going to want to push themselves to the upper limit straight out of the gate. It might not be a bad idea to begin with a 15 mg per day dosage for just eight weeks, experimenting to see how your body responds and whether or not you should elevate things for your next cycle.

A PCT protocol of between two weeks and four weeks is almost always recommended for those that have used this SARM in the past as well as those that are trying it out for the first time.

How to Stack with Other SARMs

Ostarine, like most other SARMs, can be stacked with similar compounds to elevate the performance of this supplement significantly.

Ostarine works most effectively when combined with SARMs like RAD 140, Ligandrol, and Cardarine when folks are trying to build more muscle mass in a hurry. Those that want to melt fat faster are going to want to consider combining Ostarine with SARMs like Andarine and Cardarine, as these will help you to elevate your resting metabolic rate so that you can melt fat on a 24/7 basis more effectively.


Whether or not Ostarine – or any other SARM – is picture-perfect for you will really come down to the specific goals you established for yourself and whether or not you feel comfortable using a performance-enhancing booster like this to help shortcut your progress and speed up your results.

Your own unique biochemistry will influence just how quickly and how effectively Ostarine helps as well, but you should rest easy knowing that if you choose to take advantage of this SARM it WILL provide you with a host of benefits.

Ostarine is clinically proven to deliver the goods, so to speak, and isn’t an example of modern-day snake oil. It’s also a whole lot safer than traditional steroids and performance-enhancing drugs.

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