Resveratrol is renowned for its anti-aging properties, and Dr. James Johnson has developed a pill with 200 mg of pure, high-quality trans-resveratrol. Visit our e-store today to purchase Dr. Johnson's eResveratrol™ supplements.
Resveratrol is a molecule found in red wine and also in several plants, including the Japanese knotwood. It has been shown to offer remarkable health and anti-aging benefits by activating SIRT1, or "rescue gene". Dr. James Johnson has formulated each eResveratrol™ pill to include 200 mg of pure, high-quality trans-resveratrol.
Each capsule of eResveratrol™ contains 200 mg of 99% pure trans-resveratrol from giant knotweed (polygonum cuspidatum) and 50 mg of 98% pure quercetin in a vehicle of lecithin and glycerolmonostearatcopherols to preserve freshness. Trans-resveratrol is believed to be the most active form of resveratrol.
The capsules are made in a nitrogen environment and contain an internal nitrogen bubble by Licaps®, a division of Pfizer. The nitrogen environment and nitrogen bubble help prevent eResveratrol™ from being exposed to oxygen and thus breaking down into a less effective form. This delivery system also helps ensure that eResveratrol™ is more effectively digested and absorbed by the body.
Quercetin is a polyphenol that helps to maintain the blood level of resveratrol longer. It also activates SIRT1, although more weakly than resveratrol.
Resveratrol occurs mainly as the biologically active trans- isomer, but can change to the inactive cis- version on exposure to light, heat and oxygen. For this reason, Dr. Johnson's eResveratrol™ capsules are made in a nitrogen environment with an internal nitrogen bubble to prevent oxygen exposure.
Past FDA labeling rules have required resveratrol supplements to be called red wine extracts. However recent laboratory testing has shown that there is almost no trans-resveratrol present in red wine extracts which means that this labeling policy is obsolete. The giant knotweed plant, a much more abundant and less expensive source of trans-resveratrol, is the chief source of trans-resveratrol on the market.
eResveratrol™ activates the SIRT1 gene, which is also turned on by calorie restriction. When activated, the SIRT1 gene produces special proteins that protect cells from various stressors including inflammation and free radicals.
The effect of resveratrol is dose-related. Most red wine does not contain a significant amount of resveratrol. Also, the concentration varies tremendously and therefore the dose of resveratrol in red wine is unreliable. The dramatic results of the recent mouse study by David Sinclair would have required over 100 glasses of red wine containing a maximum concentration of resveratrol. We think in terms of red wine because of the French Paradox, which suggests that small amounts of resveratrol are beneficial, but much higher doses, obtainable only from pills, are required to get the dramatic effects of the mouse study.
Studies have shown that mice experienced significant health benefits from taking 5 mg of resveratrol per kg of body weight. Many leading resveratrol researchers believe that 5 mg of resveratrol per kg of body weight is also the appropriate amount for humans to take. This translates to 200-400 mg of resveratrol per day. Although no amount of resveratrol has been shown to be toxic, further research is necessary to determine the safety of larger amounts of resveratrol.
Being classified under Federal Law as an herbal supplement, no claims can be made that eResveratrol™ will prevent, cure or treat any disease. However, there is abundant evidence that virtually all diseases of aging will probably be shown to be helped, including cancer, heart disease, stroke, diabetes, brain disorders such as Alzheimer's and Parkinson, and multiple sclerosis.
There are hundreds of published studies describing the health benefits of red wine and many studies showing resveratrol to be effective in animals. Recently a proprietary formulation of resveratrol (Sirtris SRT501) was shown to lower serum glucose levels and insulin resistance in type II diabetics, the first solid evidence of the effectiveness of resveratrol in humans that it has an anti-aging effect.
Because of the mechanism of action (SIRT1 activation), at lower doses, there may be no obvious physical changes. At higher doses, body fat loss and increased exercise endurance may be observed.
When activated, the SIRT1 gene helps inhibit fat storage by blocking a gene known as PPAR-gamma. The PPAR-gamma gene allows fat to be deposited in fat cells. When this gene is turned off, excess fat calories are burned more quickly.
However, to lose significant amounts of weight, Dr. Johnson recommends that individuals follow the UpDayDownDay Diet™ in addition to taking eResveratrol™ supplements.
Pregnant women and children are advised not to take eResveratrol™, as long term safety has not been established. It may increase bleeding time in people taking Coumadin, an anti-clotting drug use in some heart and stroke patients. In these cases, eResveratrol™ should be used with caution and under a physician's supervision.
eResveratrol™ might increase the action of certain blood pressure, cholesterol, and diabetes medications. If you take any of these medications consult your physician before taking eResveratrol™.
eResveratrol™ can be taken at any time with or without food, but should not be taken at the same time as other medications.
Individuals taking blood-thinners such as Coumadin could see some effect on clotting time and should consult with their physician before taking eResveratrol™.
Resveratrol has about 1/7000 the activity of estrogen, and taking the recommended dosage most likely exerts only a negligible effect.
Resveratrol is non-toxic according to the Environmental Protection Agency. In human clinical trials, it has shown no toxicity and it is non-toxic in animal tests at many times the recommended human dose.
On absorption in the gut and passage through the liver, resveratrol is attached to glucuronate or sulfate molecules, which prolong the duration of effect. The bioavailability, or the amount of resveratrol which actually has an effect on your cells, is determined by a variety of factors. The reason to encapsulate eResveratrol™ in nitrogen containing capsules is to prevent oxidation and degradation to the inactive form of resveratrol, known as cis-resveratrol.
Visit our e-store to purchase eResveratrol™ from Dr. James Johnson. By activating the production of special proteins that fight free radicals and inflammation, eResveratrol™ can offer remarkable anti-aging benefits and disease protection. Each eResveratrol™ pill contains 200 mg of pure trans-resveratrol.